Chalcon

http://www.e-journals.net ISSN: 0973-4945; CODEN ECJHAO E-Journal of Chemistry Vol. 5, No.1, pp. 144-148, January 2008 Synthesis and Antimicrobial Activity of just rough New Chalcones of 2-Acetyl Pyridine Y. RAJENDRA PRASAD*, P. PRAVEEN KUMAR, P. RAVI KUMAR and A. SRINIVASA RAO University College of Pharmaceutical Sciences, AndhraUniversity, Visakhapatnam-530 003, (A.P), India. dryrp@rediffmail.com Received 17 July 2007; Accepted 20 September 2007 Abstract: Six new chalcones were synthesised by elicit 2-acetyl pyridine with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation. All these compounds were characterised by means of their IR, 1H proton magnetic resonance spectroscopic data and microanalyses. The disinfectant activity of these compounds was evaluated by the transfuse plate method. Keywords: Chalcones, Synthesis, Antimicrobial activity. Introduction Chalcones either essential o r unreal are known to exhibit divers(a) biological activities. They pack been heralded to possess antioxidant,1-4 antimalarial,5 antileishmanial,6 antiinflammatory,7 antitumor8 and antibacterial activity9.

The armorial bearing of a excited ?,?-unsaturated keto function in chalcones is found to be responsible for their antimicrobial activity, which may be altered depending on the type and military strength of substituent on the evocative rings. In the present communication we report the reaction of 2-acetyl pyridine with different aromatic aldehydes to form chalcones (1-6). The structures of the various synthesized compounds were assign on the basis of primary(a) analyses, IR and 1 H proton magnetic resonance spectral data. ! These compounds were also screened for their antimicrobial activity. data-based Melting points were determined on a capillary melt point apparatus and are uncorrected. 1 H NMR spectra was save in the indicated solvent on Bruker WM 400 megahertz spectrometer with TMS as internal standard. infrared frequency spectra were recorded in KBr on...If you want to get a complete essay, magnitude it on our website: OrderEssay.net

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